What time does San Francisco 49ers-Indianapolis Colts NFL game start?
Kickoff is scheduled for Monday, December 22, 2025 at 8:15 PM EST at Lucas Oil Stadium.
Final score: Indianapolis Colts 27 — San Francisco 49ers 48.
What channel is San Francisco 49ers vs. Indianapolis Colts on tonight?
The Indianapolis Colts vs San Francisco 49ers game is broadcast across 49 broadcasters worldwide. Below you'll find a comprehensive broadcast partner list. Choose your preferred commentary language from the options below.
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2025 San Francisco 49ers schedule
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2025 Indianapolis Colts schedule
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2025 NFL team schedules: complete team-by-team schedule of games
Want the league-wide slate in one place? The NFL schedule hub lists every team's matchup in chronological order with national TV windows and streaming notes.